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The intense lipid oxidation disrupts ion balance within the cell, leading to reduced membrane flexibility, increased permeability and the formation of protein-based pores

It's advisable to perform the mixing process in a clean area free of clutter and potential contaminants

10.1016/j.cell.2011.11.031 Cell 276 SzirkiI.MohanakumarK

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Wei Y, Zhou Z, Zhang Z, Zhao L, Li Y, Ma Q, Liang M, Xu H

Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues